Core Berberine Blend by Energetix
Core Berberine Blend is a spagyrically prepared botanical extract of barberry root bark, coptis rhizome, Oregon, grape root, goldenseal rhizome, and lemon balm leaf that may support
• Beneficial gut flora & intestinal epithelial integrity
• Digestion, assimilation & elimination
• Healthy liver, gallbladder & digestive tract function
• Glucose & lipid metabolism
• Healthy immune function
• Normal inflammation response
Biological Response: The Gut Microbiota & Immune Health
Immune health relies heavily on digestive health. When flourishing, the gut microbiota regulates the immune system through complex molecular signaling. The gastroprotective effects of
herbal bitters such as goldenseal and lemon balm—especially their promotion of beneficial intestinal bacteria—establish a supportive terrain for healthy immune function.
The alkaloid berberine increases blood flow to the spleen, the body’s largest lymphatic organ that stores
immune cells known as lymphocytes (T cells, B cells). Berberine also enhances immunity by activating macrophages, white blood cells that identify unfamiliar substances and recruit other immune cells for broadened
Biological Response: Inflammation Response &
When released from cell membranes, arachidonic acid is converted
enzymatically to several bioactive lipids known as eicosanoids. As
hormonal messengers, eicosanoids—which include prostaglandins, thromboxanes, and leukotrienes—communicate with other signaling molecules
to coordinate the inflammation response and regulate numerous homeostatic functions.
Alkaloids and terpenes found in barberry, goldenseal, coptis, Oregon
grape, and lemon balm inhibit important inflammatory mediators such as
COX-2, 5-LOX, nitric oxide, TNF, and NF-kB. The alkaloid berberine suppresses the release
of arachidonic acid from cell membranes, thus preventing its initiation of the prostaglandin cascade.
Core Berberine Blend is sourced from Berberis vulgaris, Coptis chinensis, Mahonia aquifolium, Hydrastis
canadensis, and Melissa officinalis. Whether a broadleaf, prickly shrub like Oregon grape (Mahonia aquifolium) or a small, evergreen perennial such as coptis (Coptis chinensis), most of these seemingly diverse plants
contain berberine, an isoquinoline alkaloid that colors their roots and rhizomes a vivid yellow.
By contrast, lemon balm’s fragrant leaves are dominated not by alkaloids but phenolic acids, flavonoids, and
terpenes. These unique compounds work synergistically with berberine to elicit a range of biochemical and
physiological responses including among others smooth muscle relaxation, blood lipid balance, and peripheral vasodilation.
Spagyrically Prepared Botanicals
Core Berberine Blend is prepared using a unique handcrafted method known as spagyric processing. A
branch of the medieval science known as alchemy and the forerunner of modern chemistry, spagyria is an
herbal manufacturing method first described in the early 16th century by the Swiss physician Paracelsus in
his book Liber Paragranum. The word comes from the ancient Greek σπάω, spao ‘to draw out’ and άγείρω,
ageiro ‘to gather.’ Its essential meaning is ‘to separate and join.’