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DB12  Digest Vit. B12 by Systemic Formulas DB12 - Digest Vit. B12 by Systemic Formulas

DB12 - Digest Vit. B12 by Systemic Formulas


Digestive enzymes, vitamins, nutrients, and herbalomic® botanicals that support the stomach’s parietal cells that produce intrinsic factor—a glycoprotein essential for the absorption of Vitamin B12.

Bio Function

MSRP: $46.00
Member Price: $43.00
Save: $3.00
MegaSporeBiotic by Microbiome Labs MegaSporeBiotic by Microbiome Labs

MegaSporeBiotic by Microbiome Labs

MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic clinically shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains efficacy during antibiotic therapy.

MSRP: $55.00
WheatRescue by Microbiome Labs WheatRescue by Microbiome Labs

WheatRescue by Microbiome Labs

There’s no denying that gluten is problematic for many people. Many doctors will suggest a strict gluten-free diet, but recent discoveries have revealed this may not be enough. New research suggests that the small intestines of up to 60% of adults with celiac disease never completely heal despite following a gluten-free diet. This could be due in part to gluten contamination in many “gluten-free” foods. A recent study examined 5,624 foods tested by 804 users and found that 32% of foods labeled “gluten-free” contained measurable amounts of gluten. Interestingly, gluten-free pizzas and pastas were the most likely to test positive for gluten with over 50% of samples showing gluten contamination.

WheatRescue™ is a unique blend of powerful digestive enzymes and probiotics designed to support optimal gluten digestion and protect against hidden sources of gluten. DPP-IV and Tolerase G® are specific enzymes that assist in the breakdown of glutenin and gliadin proteins, which can help alleviate symptoms associated with dietary gluten intolerance and sensitivity. WheatRescue™ combines resilient probiotic spores with superior digestive enzymes to support the complete digestion of gluten and other inflammatory wheat-derived peptides within 60 to 90 minutes.

But beyond the risk of gluten contamination, a gluten-free diet does not appear sufficient for repairing intestinal damage. In one study from 2010 of 241 subjects with celiac disease, only 35% of subjects saw mucosal recovery of the small intestine after 2 years of following a gluten-free diet, and only 66% saw mucosal recovery after 5 years of eating a gluten-free diet. Another study from 2009 examined 465 celiac subjects who adhered to a gluten-free diet for 16 months and found that total restoration of the intestinal damage inflicted by gluten was exceptionally rare (roughly 8%) in adult celiac patients despite following a gluten-free diet.4 These findings suggest that while a gluten-free diet can help to prevent further damage, the avoidance of gluten alone is not sufficient for total gut restoration.
A combination of probiotic spores and yeast can effectively support intestinal health and barrier function. Saccharomyces boulardii is a probiotic yeast that can help support digestive health by producing lactate, B vitamins, and targeted antimicrobials to defend against pathogenic gut infections. S. boulardii has also been shown to be immunoprotective through the upregulation of IgA and IgG secretions in the intestines. Bacillus coagulans and Bacillus subtilis are spore-forming probiotics that are naturally designed to survive digestion, support intestinal barrier function, and enhance the microbial diversity of the gut microbiome.
B. coagulans is very unique in that it possesses characteristics of both Bacillus and Lactobacillus genera. It functions as a lactic acid-producing bacterium with the protection and survivability of a Bacillus spore. Bacillus subtilis HU58™ provides potent immune modulation and has been shown to reduce pro-inflammatory cytokines IL-6 and TNF and significantly increase the production of short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate in the gut. Butyrate is the major energy source for colonocytes and has been studied for its role in nourishing the colonic mucosa.
A recent study published in Scientific Reports concluded that microbially-derived byproducts like butyrate and lactate can be used to modulate the epithelial response to gluten by improving barrier function and reducing gliadin induced cytokine secretion.When it comes to facing the dangers of gluten, WheatRescue™ is here to save the day. WheatRescue™ offers complete digestive support, superior protection, and peace of mind concerning gluten.

MSRP: $55.00
MegaPreBiotic by Microbiome Labs MegaPreBiotic by Microbiome Labs

MegaPreBiotic by Microbiome Labs

MegaPreBiotic™ is the first Precision Prebiotic™ supplement made up of clinically-tested, non-digestible oligosaccharides that can increase microbial diversity and selectively feed beneficial bacteria like Akkermansia muciniphila, Faecalibacterium prausnitzii, and Bifidobacteria. MegaPreBiotic™ REINFORCES the beneficial microbial changes created by MegaSporeBiotic™ to promote a strong and diverse microbiome.

MSRP: $55.00
MegaMucosa by Microbiome Labs MegaMucosa by Microbiome Labs

MegaMucosa by Microbiome Labs

MegaMucosa is the first complete mucosal support supplement of its kind, formulated to REBUILD a healthy mucosal barrier. MegaMucosa also contains dairy-free immunoglobulins clinically shown to support a healthy immune response in the mucosa and a state-of-the-art flavobiotic clinically shown to support microbial diversity and alleviate barrier dysfunction, otherwise known as leaky gut.

The mucosal system is a very important part of the human immune system. Not many people think of mucus as being protective, but it is the main interface between the human body and the outside world. The mucosal system contains 150 times more surface area than skin, which makes it one of the most important immune barriers. The health of the mucosa determines how the body interacts with antigens; therefore, the integrity of the intestinal mucosa can dictate overall immune function.

MSRP: $55.00
MegalgG2000 by Microbiome Labs MegalgG2000 by Microbiome Labs

MegalgG2000 by Microbiome Labs

MegaIgG2000 is a dairy-free immunoglobulin concentrate that supports healthy digestion,binds environmental toxins and maintains healthy gut barrier function. Unlike other milk-derived immunoglobulins on the market, Mega IgG2000 is derived from bovine serum, making it lactose-free, casein-free, and β-lactoglobulin-free.

This unique alternative to bovine colostrum supports a healthy mucosal immune system by decreasing immune activation and strengthening gut barrier function. The serum immunoglobulin in Mega IgG2000 has been the subject in over 10 published human clinical trials.

When an antigen enters the body, it elicits a response from the innate and adaptive branches of the immune system. The adaptive immune response utilizes B and T lymphocytes to find foreign antigens, neutralize them, and eliminate them from the body. B lymphocytes do this by producing antibodies, or immunoglobulins, that can bind to unwanted antigens and remove them from the system.

Immunoglobulin G (IgG), the most abundant antibody in the system, can be found in blood and extracellular fluid, allowing it to control infections in the body. IgG antibodies can bind a variety of pathogens, including bacteria, viruses, and fungi, as well as their toxic by-products. Binding these toxins will neutralize them and allow the immune system to safely remove them from the body.


Research:

DETZEL CJ, HORGAN A, HENDERSON AL, PETSCHOW BW, WARNER CD, MAAS KJ, ET AL.
Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PloS one. 2015;10(4):e0120278.
KUCHIBHATLA R, PETSCHOW BW, ODLE J, WEAVER EM.
Nutritional Impact of Dietary Plasma Proteins in Animals Undergoing Experimental Challenge and Implications for Patients with Inflammatory Bowel Disorders: A Meta-analysis. Adv Nutr. 2015;6(5):541-51.
PEREZ-BOSQUE A, MIRO L, MAIJO M, POLO J, CAMPBELL J, RUSSELL L, ET AL.
Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. American journal of physiology Gastrointestinal and liver physiology. 2015;308(12):G1012-8.
WILSON D, EVANS MD, WEAVER E, SHAW AL, KLEIN GL.
Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome. Clinical Medicine Insights: Gastroenterology. 2013;6:49-60.
ASMUTH DM, MA ZM, ALBANESE A, SANDLER NG, DEVARAJ S, KNIGHT TH, ET AL.
Oral Serum-Derived Bovine Immunoglobulin Improves Duodenal Immune Reconstitution and Absorption Function in Patients with HIV Enteropathy. Aids. 2013;27:2207-17.

MSRP: $55.00
RestorFlora by Microbiome Labs RestorFlora by Microbiome Labs

RestorFlora by Microbiome Labs

RestorFlora is a probiotic supplement that combines well-studied and widely-used probiotic strains Saccharomyces Boulardii, Bacillus Subtilis HU58, and Bacillus Clausii. This combination of probiotic yeast and bacteria offers comprehensive digestive flora support with an advanced, dual-action approach to maintain a healthy intestinal environment.

Saccharomyces boulardii is well studied and extensively used for its ability to curb digestive issues associated with antibiotic use. However, a product containing only S. boulardii has limitations with regards to other probiotic functions. RestorFlora represents a significant advancement that overcomes these limitations with the addition of Bacillus Subtilis HU58 and Bacillus Clausii. RestorFlora provides competitive exclusion of bad and potentially harmful organisms, as well as the ability to colonize in the digestive tract to produce favorable immune responses.


Benefits of RestorFlora
  • Supports a balanced intestinal flora
  • Promotes intestinal health
  • Supports healthy bowel movement
  • Aids in digestion
  • Detoxifies the intestinal tract
  • Supports healthy immune function
  • Maintains regularity

MSRP: $43.00
HU58 by Microbiome Labs HU58 by Microbiome Labs

HU58 by Microbiome Labs

HU58™ is a high potency dose of Bacillus subtilis HU58, formulated to enhance the efficacy of MegaSporeBiotic™. HU58™ can produce over 12 targeted antibiotics in the intestines, which makes it particularly effective in balancing intestinal microflora.

High Potency Bacillus Subtilis is recommended with:

  • Frequent travel
Benefits of High Potency Bacillus Subtilis
  • 100% survivability in the digestive tract
  • 40% increase in short-chain fatty acid (SCFA) production
  • Maintains healthy digestion
  • Supports healthy immune function
  • Effective during antibiotic therapy

MSRP: $43.00
MegaGuard by Microbiome Labs MegaGuard by Microbiome Labs

MegaGuard by Microbiome Labs

MegaGuard™ is a novel digestive aid that combines protective licorice polyphenols, cleansing artichoke leaf extract, and soothing ginger to promote normal digestion, regulate stomach acid, balance H. pylori levels, and reduce occasional digestive discomforts such as gas, bloating, and indigestion. With the power of these herbs combined, MegaGuard™️ provides unique and comprehensive digestive support, bowel regularity, and gastric protection.

GUTGARD® LICORICE FLAVONOIDS | 75 mg

Licorice (Glycyrrhiza glabra) has a long history of use for treating digestive discomforts. In Ayurvedic and Traditional Chinese Medicine, licorice is well-known for its ability to protect the gastric mucosa and modulate everyday inflammation. One of the most commonly known active ingredients in licorice is a saponin called glycyrrhizin that has been used as an emulsifier and sweetener in the food industry. However, most supplements contain deglycyrrhizinated licorice (DGL) because large amounts of glycyrrhizin have been associated with serious adverse side effects like elevated blood pressure and lowered potassium levels.

Gutgard® licorice flavonoids are entirely different from DGL with respect to chemistry, composition, manufacturing, and mechanisms of action. While a classical extract of DGL does not contain any significant quantity of flavonoids, Gutgard® is standardized to contain more than 10% total flavonoids and less than 0.5% glycyrrhizin to avoid undesirable effects. More than 50 flavonoids have been identified in Gutgard® which have been shown to have beneficial activity for digestive complaints. In fact, Gutgard® licorice flavonoids have been shown to protect the stomach lining and balance Helicobacter pylori levels much more effectively than regular DGL extracts. Gutgard® licorice can also relieve occasional indigestion, bloating, and stomach pain at 150mg/day.
ARTICHOKE LEAF EXTRACT | 320 mg
Artichoke (Cynara scolymus) leaf extract (ALE) has also been used in traditional medicine as a digestive aid. The bitter compounds, particularly cynaropicrin, are responsible for the digestive benefits of artichoke. ALE has been shown to increase bile production, protect the liver, balance blood lipids, and act as an antispasmodic.

In 2003, German researchers demonstrated that 640mg/day of artichoke leaf extract significantly improved digestive symptoms like bloating and fullness as well as quality of life in 244 patients with functional dyspepsia. Though the study was conducted over 6 weeks, the majority of the treatment group saw relief of their digestive symptoms in the first week.
GINGER ROOT EXTRACT (20%) | 30 mg
Ginger (Zinziber officinalis) has been used as a digestive aid in Eastern medicine for generations. Studies have demonstrated that ginger accelerates gastric emptying and can relieve occasional bouts of nausea and vomiting. Gingerols and shogaols, the active polyphenolic compounds in ginger, appear to be responsible for such effects by weakly inhibiting cholinergic M3 and serotonergic 5-HT3 receptors, whose temporary dysfunction is responsible for nausea, vomiting, and hypomotility.

Ginger extracts with a higher gingerol content (20-30% gingerols) are stronger and more effective at relieving digestive discomforts. In 2015, an Italian study of 126 patients found that the daily combination of 40 mg of ginger extracts (25-30% gingerols) with 200 mg of artichoke leaf extracts reduced the severity and frequency of common digestive symptoms like nausea, bloating, early satiety, and abdominal pain 17% more effectively than just artichoke leaf extract alone. While most ginger extracts only contain 5% gingerols, MegaGuardTM contains 60 mg of high potency ginger root extract (20% gingerols) for maximum strength.


Research:
WITTSCHIER N, ET AL.
Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. Journal of Ethnopharmacology. 2009;125(2): 218–223.
OMAR HR, ET AL.
Licorice abuse: time to send a warning message. Therapeutic Advances in Endocrinology and Metabolism. 2012;3(4): 125–138.
ASHA MK, ET AL.
Effect of Flavonoid-Rich Extract of Glycyrrhiza glabra on Gut-Friendly Microorganisms, Commercial Probiotic Preparations, and Digestive Enzymes. J Diet Suppl. 2017;14(3):323-333.
GEBHARDT R, FAUSEL M.
“Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Toxicology in Vitro. 1997; 11(5):669–672.
GEBHARDT R.
Inhibition of hepatic cholesterol biosynthesis by artichoke leaf extracts is mainly due to luteolin. Cell Biology and Toxicology. 1997;13:58.
BROWN JE, RICE-EVANS CA.
Luteolin-rich artichoke extract protects low density lipoprotein from oxidation in vitro. Free Radical Research. 1998;29(3):247–255.
PEREZ-GARCIA F, ET AL.
Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radical Research. 2000;33(5): 661–665.
RECHNER AR, ET AL.
Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo. Free Radical Research. 2001;35(2):195–202.
ISHIDA K, ET AL.
Effects of artichoke leaf extract on acute gastric mucosal injury in rats. Biological and Pharmaceutical Bulletin. 2010;33(2):223–229.
EMENDORFER F, ET AL.
Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum. Biological and Pharmaceutical Bulletin. 2005;28(5): 902–904.
HOLTMANN G, ET AL.
Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial. Ailment Pharmacy Ther. 2003;18:1099-1105.
COMMITTEE ON HERBAL MEDICINAL PRODUCTS.
Assessment report on Zingiber officinale Roscoe, rhizome. European Medicines Agency. 2011; EMA/HMPC/577856.
WU KL, ET AL.
Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol & Hepatol. 2008; 20(5): 436–440.
FORD AC, ET AL.
The Rome III criteria for the diagnosis of functional dyspepsia in secondary care are not superior to previous definitions. Gastroenterology. 2014;146(4):932–940.
HAAG S, ET AL.
Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters. Gut. 2004; 53(10): 1445–1451.
GIACOSA A, ET AL.
The effect of Ginger (Zinziber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2015;2015:1-9.


MSRP: $55.00
   
 
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